Caroline Einen started her PhD on August 10th, 2020 at PoreLab NTNU. Caroline holds a Master of Science in nanotechnology with a specialization in Bionanotechnology from NTNU. Her project is part of the project “Ultrasound-mediated transport of nanoparticles in tissue: A predictive model” financed by the Research Council of Norway. This project was established by Professor Ruth Catharina de Lange Davies and Professor Signe Kjelstrup .
Caroline presents her PhD project as follow:
“Nanoparticles (NPs) loaded with therapeutic agents can be used as vesicles for delivery of drugs to tumors for reduced toxic effects in healthy tissue. A specific approach to achieve improved targeted delivery is to combine NPs with microbubbles (MB) and focused ultrasound treatments (FUS). Application of FUS in the presence of MBs can cause the MB to oscillate or implode, which in turn give mechanical forces that facilitate extravasation of the NPs from the vasculature and further push the NPs further into tissue, a strategy that has shown enhanced delivery of drugs to tumors.
My project aims to increase the understanding of the underlying mechanisms governing the success of NP delivery to tumor tissue using the MB and FUS combination. My work is a part of the research project ““Ultrasound-mediated transport of nanoparticles in tissue: Creating a predictive model combining theory, simulations and experiments” funded by the Research Council of Norway. I will investigate the process of NP transport in tissue experimentally, where PhD candidate Sebastian Price will attempt to make a predictive model based on the experimental data, resulting in a tool for designing the optimum FUS treatment for effective NP delivery“.
Her supervisors are: Catharina de Lange Davies, Rune Hansen, Einar Sulheim and Signe Kjelstrup.